September 16, 2021 in FDA Update

FDA approves mobocertinib for NSCLC with EGFR exon 20 insertion mutations

The US FDA has granted an accelerated approval to mobocertinib for the treatment of patients with locally advanced or metastatic nonsmall cell lung cancer (NSCLC) with epidermal growth factor receptor…
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September 12, 2021 in New Drug

Novel diabetic foot ulcer cream shows promise in phase 3 trial

ON101 (Fespixon, Oneness Biotech), a first-in-class, macrophage-regulating, wound-healing cream for diabetic foot ulcers has shown benefit over absorbent dressings in a phase 3 trial, with another trial ongoing. The published…
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September 12, 2021 in 1 min

Subcutaneous Inj. vedolizumab appears to be effective maintenance therapy in IBD-UC

Subcutaneous vedolizumab appears to be an effective and safe maintenance therapy for some patients with moderate to severe active Crohn's disease, according to results of a phase-3 trial. Vedolizumab, the…
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August 31, 2021 in FDA Update

FDA approves first vagus nerve stimulation system for stroke rehab

The US FDA has approved the Vivistim System (MicroTransponder), a first-of-its kind vagus nerve stimulation (VNS) system intended to treat moderate-to-severe upper extremity motor deficits associated with chronic ischemic stroke.…
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August 31, 2021 in 1 min

Dapagliflozin might reduce the risk for ventricular arrhythmias in HFrEF

The addition of dapagliflozin to standard therapy reduced the relative risk for the primary composite endpoint of any serious ventricular arrhythmia, resuscitated cardiac arrest, or sudden death by 21%. Dapagliflozin…
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August 31, 2021 in FDA Update

FDA approves Brivaracetam for seizures in children as young as 1 Month

The approval covers all three brivaracetam (BRIVIACT) formulations (tablets, oral solution, and IV) and marks the first time the IV formulation will be available for children. Dosage: Dose for adults…
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August 25, 2021 in FDA Update

FDA approves TAVR System in severe AS

The US Food and Drug Administration has approved Medtronic's Evolut FX system for transcatheter aortic valve replacement (TAVR) in patients with symptomatic severe aortic stenosis at all risk levels. The…
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August 25, 2021 in 1 min

FDA approves new indication for Rivaroxaban in PAD

The US FDA has approved an expanded peripheral artery disease (PAD) indication for the direct oral anticoagulant rivaroxaban to include patients who have undergone recent lower-extremity revascularization due to symptomatic…
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August 25, 2021 in New Drug

Bimekizumab approved in Europe for Psoriasis treatment

Bimekizumab (Bimzelx), a humanized IgG1 monoclonal antibody, is the first approved treatment for moderate to severe plaque psoriasis that selectively inhibits interleukin (IL)–17A and IL-17F. Dose: 320 mg, given in…
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August 18, 2021 in FDA Update

FDA has expanded indication for the noninvasive Deep TMSTM

The US Food and Drug Administration (FDA) has expanded indication for the noninvasive BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMSTM) System to include treatment of comorbid anxiety symptoms in adult…
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August 15, 2021 in COVID-19

Microscopic lung damage may continue in ‘Long COVID’

The persistent breathing issues that plague some COVID-19 survivors, known as 'long COVID,' may be due to microscopic processes that continue to damage lungs even after the acute infection is…
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August 14, 2021 in 1 min

A new monoclonal antibody named CIS43LS prevents malaria in new trial

A new monoclonal antibody discovered and developed at the National Institutes of Health safely prevented malaria for up to 9 months in people who were exposed to the malaria parasite.…
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August 14, 2021 in 1 min

Icotinib is the best adjuvant chemotherapy for EGFR-mutant NSCLC

Icotinib is a highly selective, first-generation EGFR tyrosine kinase inhibitor (TKI) approved in China as first-line monotherapy in patients with NSCLC with somatic EGFR mutations. Following complete resection of EGFR-mutant…
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August 3, 2021 in 1 min

Physicians wearing white coats rated more experienced

Physicians wearing white coats were rated as significantly more experienced and professional than peers wearing casual attire. Regardless of their attire, however, female physicians were more likely to be judged…
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August 3, 2021 in Article

New guideline for replacement of ART: CAB/RPV LA not for everyone

Approved by the FDA in late January 2021, CAB/RPV LA (cabotegravir/rilpivirine) is considered an optimization strategy for individuals with HIV whose virus is suppressed by oral ART and who might…
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August 1, 2021 in 1 min

Restoring pulmonary endothelial cells reverses emphysema in mice

Correcting endothelial dysfunction in both human tissue and an elastase-induced murine model of emphysema shows promise in stopping and reversing the course of the disease, according to an international group…
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August 1, 2021 in 1 min

New investigational helmet device shrinks glioblastoma

A case report describes a novel helmet device that generates a noninvasive oscillating magnetic field and that shrunk a glioblastoma tumor by about a third. The patient had end-stage recurrent…
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July 30, 2021 in COVID-19

Delta variant of COVID-19 as contagious as chickenpox

Internal Centers for Disease Control and Prevention (CDC) documents support the high transmission rate of the delta variant and put the risk in easier to understand terms. The documents also…
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July 30, 2021 in 1 min

Lenvatinib plus Gefitinib therapy promising in liver cancer

In patients with advanced liver cancer who were unresponsive to lenvatinib, adding gefitinib (an EGFR inhibitor) led to a clinically meaningful response in a proof-of-concept study. 12 patients with advanced…
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July 27, 2021 in 1 min

Urinary thromboxane B2 may be marker of aggressive prostate cancer in black men

Upregulation of urinary thromboxane B2 may be a new marker of aggressive prostate cancer in African American men, a group that bears a disproportionately high burden of lethal prostate cancer.…
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July 27, 2021 in COVID-19

Corneal changes may signal long COVID

Nerve fiber loss and an increase in dendritic or key immune cells on the cornea may help identify Long COVID, according to a small study published online today in the…
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July 21, 2021 in 1 min

Ficlatuzumab + chemo shows early promise in refractory AML

The combination of ficlatuzumab plus chemotherapy showed considerable early promise in relapsed/refractory acute myeloid leukemia (AML) in a small phase-1 study. Ficlatuzumab is an investigational, first-in-class monoclonal antibody that binds…
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July 21, 2021 in FDA Update

FDA approves spinal cord stimulation for diabetic neuropathy pain

The Food and Drug Administration has approved the first high-frequency spinal cord stimulation (SCS) therapy for treating painful diabetic neuropathy (PDN). The approval is specific for the treatment of chronic…
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July 18, 2021 in 1 min

China’s first human infection case with Monkey B virus dies

A Beijing-based veterinarian who was confirmed as China's first human infection case with Monkey B virus (BV) has died. The 53-year-old male vet, who worked for an institution researching on…
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July 18, 2021 in 1 min

Three new drugs linked with ANCA-associated vasculitis

The overactive bladder treatment mirabegron (Myrbetriq) is one of three new drugs to be linked to cases of drug-associated antineutrophil cytoplasmic antibody-associated vasculitis (DA-AAV) according to pharmacovigilance data. The other…
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July 18, 2021 in New Drug

New drugs for migraine

Five recently approved acute migraine treatments were specifically noted: two small-molecule calcitonin gene-related peptide (CGRP) receptor antagonists — rimegepant and ubrogepant — along with the nonsteroidal anti-inflammatory drug celecoxib, the…
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July 14, 2021 in 1 min

Prasugrel better than Ticagrelor in ACS patients undergoing PCI

The ISAR-REACT 5 trial has demonstrated the superiority of prasugrel to ticagrelor for patients presenting with ACS. Ticagrelor and prasugrel are both potent inhibitors of the P2Y12 receptor, but their…
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July 11, 2021 in FDA Update

FDA approves Finerenone for slowing CKD in T2DM

The FDA approved the anti-mineralocorticoid agent finerenone (Kerendia) for slowing the progression of chronic kidney disease in type 2 diabetes patients. The first non-steroidal, selective mineralocorticoid receptor antagonist was approved…
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July 11, 2021 in FDA Update

Lenvatinib-Pembrolizumab combo promising in advanced kidney cancer

The combination of the multikinase inhibitor lenvatinib and the anti-PD-1 antibody pembrolizumab has "encouraging" antitumor activity and a manageable side effect profile and might be an option following immune-checkpoint inhibitor…
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July 7, 2021 in COVID-19

Study shows tocilizumab and sarilumab reduce COVID-19 deaths

Treating critically ill COVID-19 patients with arthritis drugs tocilizumab and sarilumab significantly improves survival rates and reduces the amount of time patients need intensive care. The immunosuppressive drugs, Actemra, also…
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July 6, 2021 in 1 min, Article

Insulin-Pramlintide combo improves type 1 diabetes control

A novel investigational coformulation of prandial insulin and pramlintide improves blood glucose control and reduces body weight in people with type 1 diabetes, early research suggests. The injectable product combines…
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July 6, 2021 in 1 min

Adalimumab safe and effective in children with UC

Adalimumab is effective and well-tolerated in children with moderate-to-severe ulcerative colitis (UC), with "clinically meaningful" rates of clinical remission and response, including steroid-free remission and mucosal healing, according to results…
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July 1, 2021 in 1 min, Article

What’s best for diabetes after metformin? GRADE trial states

Liraglutide and insulin glargine outperformed glimepiride and sitagliptin as single add-on agents to metformin for treating patients with type 2 diabetes in a multicenter US trial that randomized just over…
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June 29, 2021 in COVID-19

Hepatitis C antivirals may fight SARS-CoV-2

Sofosbuvir/ledipasvir and nitazoxanide both appeared to clear SARS-CoV-2, the virus that causes COVID-19 in a preliminary trial, said Mohamed Medhat, lecturer in the department of gastroenterology and tropical medicine at…
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June 29, 2021 in 1 min, Article

EC approves Cemiplimab for advanced or metastatic BCC after HHI therapy

The European Commission (EC) has approved cemiplimab (Libtayo) for the treatment of adults with locally advanced or metastatic basal cell carcinoma (BCC) who progressed on or could not tolerate treatment…
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June 23, 2021 in Article, FDA Update

FDA approves first oral anticoagulant for children

The US Food and Drug Administration (FDA) has approved dabigatran etexilate (Pradaxa) oral pellets for the treatment of venous thromboembolism (VTE) in children aged 3 months to less than 12…
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June 19, 2021 in FDA Update

FDA approves StrataGraft for deep skin burns

The US FDA has approved a novel regenerative therapy that could be an alternative to autografting for treating adults with severe burns. The new treatment, StrataGraft, is a bilayer tissue-engineered…
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June 16, 2021 in Article, COVID-19

‘COVID Toes’ Chilblain-like lesions not related to COVID-19

Chilblain-like lesions seen in adolescents during the COVID-19 pandemic are nonischemic and not related to systemic or localized SARS-CoV-2 infection, suggests a case series from Italy. These lesions "most likely…
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June 16, 2021 in 1 min, Article

Saliva test to detect HPV-associated throat cancer

A novel saliva test has been shown to detect HPV-associated oropharyngeal squamous cell carcinoma (OPSSC) with high accuracy in a small study. If the results are validated in subsequent studies,…
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June 13, 2021 in Article, COVID-19

Noninvasive ventilation tied to higher mortality than CPAP in COVID-19 Pneumonia

Compared with continuous positive airway pressure (CPAP), the use of non-invasive ventilation (NIV) to treat acute respiratory failure secondary to COVID-19 pneumonia is tied to higher mortality, according to a…
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June 10, 2021 in Article, FDA Update

FDA approves Brincidofovir to treat smallpox

The US FDA has approved Chimerix's brincidofovir (BCV, Tembexa) to treat smallpox. Fearful of a possible bioweapon attack, the United States has been steadily preparing a defense through the Biomedical…
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June 7, 2021 in Article, FDA Update

FDA approves new drug treatment for chronic weight management

The US FDA approved Wegovy (semaglutide) injection a GLP-1 receptor agonists (2.4 mg once weekly SC) for chronic weight management in adults with obesity or overweight with at least one…
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June 5, 2021 in 1 min, Article

Gene variant confirmed as strong predictor of lung disease in RA

Patients with rheumatoid arthritis who carry a specific allele of the gene MUC5B have about double the risk of developing interstitial lung disease when compared with noncarriers, according to a…
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June 4, 2021 in 1 min, Article

Use belimumab after rituximab in patients with SLE

Using belimumab after rituximab to treat patients with systemic lupus erythematosus (SLE) refractory to conventional therapy not only significantly decreased levels of serum IgG anti-dsDNA antibody levels but also prolonged…
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June 4, 2021 in Article, New Drug

Toripalimab improves survival in nasopharyngeal cancer

Toripalimab is a monoclonal antibody that blocks programmed cell death protein 1 (PD-1), developed in China and recently approved there for the third-line treatment of NPC, among other indications. The…
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June 2, 2021 in Article, COVID-19

India variant shows resistance to antibody drugs & vaccines

Antibody drugs and COVID-19 vaccines are less effective against a coronavirus variant that was first detected in India, researchers say. The variant, B.1.617.2, has mutations that make it more transmissible.…
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June 2, 2021 in 1 min, Article

Lifileucel promising against unresponsive malignant melanoma

Lifileucel shows promise in metastatic-melanoma patients whose disease had progressed on standard immune-checkpoint inhibitors (ICI) and other therapies, according to a small open-label trial. "Lifileucel is a ground-breaking form of…
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May 30, 2021 in Article, FDA Update

FDA approves first drug for lung cancer with KRAS mutation

Sotorasib (Lumakras), specifically targets the KRAS G12C mutation, which accounts for about 13% of NSCLC mutations. KRAS mutations are the most common mutations to occur in NSCLC tumors, accounting for…
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May 29, 2021 in 1 min, Article

Hybrid therapy for H. pylori infection

A 14-day course of hybrid therapy was as effective as 10-day bismuth quadruple therapy, but with fewer side effects, according to results of a randomized trial conducted in Taiwan. In…
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May 29, 2021 in Article, FDA Update

FDA approves Ozanimod for Ulcerative Colitis

The US FDA has approved ozanimod (Zeposia) for adults with moderately to severely active ulcerative colitis (UC), the company has announced. Ozanimod (0.92 mg), an oral medication taken once daily,…
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May 25, 2021 in 1 min, Article

Mild cortisol excess increases mortality in adrenal incidentaloma

Mortality is two to three times higher in patients with adrenal incidentalomas who have autonomous cortisol secretion levels of 83 nmol/L (3 µg/dL) or more after a 1 mg dexamethasone…
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May 25, 2021 in Article, New Drug

A novel drug most effective in sickest HFrEF patients

The greatest relative benefit from omecamtiv mecarbil, a novel myotropic drug class that improves cardiac performance, is produced in heart failure patients with the lowest left ventricular ejection fraction (LVEF),…
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May 25, 2021 in 1 min, Article

Sotagliflozin improves clinical outcomes in patients with HFpEF

The investigational sodium-glucose cotransporter (SGLT) 1/2 inhibitor sotagliflozin is the first agent clearly shown in a prespecified analysis of randomized trials to improve clinical outcomes in patients with heart failure…
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May 19, 2021 in Article

Management protocol for Mucormycosis by AIIMS Rishikesh

Management by Inj Liposomal amphotericin B (LAmB): Test dose •Inj. Liposomal Amphotericin- B 1 vial (50 mg) to be diluted in 12 ml of the diluent and 0.25ml (1 mg)…
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May 19, 2021 in Article, New Drug

Novel IL-6 antibody reduces CRP up to 92% in High-risk ASCVD

Inhibition of interleukin (IL)-6 with ziltivekimab reduces multiple biomarkers of inflammation and thrombosis in patients at high atherosclerotic risk with moderate to severe chronic kidney disease (CKD) and elevated C-reactive…
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May 18, 2021 in Article, COVID-19

Antibody status & incidence of SARS-CoV-2 infection in health care workers

The relationship between the presence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection remains unclear. The presence of anti-spike or anti-nucleocapsid IgG…
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May 18, 2021 in Article, COVID-19

ICMR releases guidelines for COVID-19 associated Mucormycosis

The correlation between COVID-19 and Mucormycosis isn't surprising, as the biggest risk factors are uncontrolled diabetes and immune suppressant steroids. Rhino-orbital-cerebral and pulmonary infections are the most common syndromes caused…
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May 18, 2021 in 1 min, Article

Statins: A potential treatment in COVID-19?

In the HARP-2 trial of simvastatin in acute respiratory distress syndrome (ARDS), published a few years ago, the main results were neutral, but in the subgroup of patients with hyperinflammatory…
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May 18, 2021 in Article

Trastuzumab Deruxtecan has promising activity in Advanced Colorectal Cancer

Trastuzumab deruxtecan, an antibody-drug conjugate, showed "promising and durable activity" in HER2-positive metastatic colorectal cancer (CRC) refractory to standard treatment in an open-label phase-2 trial. HER2 amplification is seen in…
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May 9, 2021 in 1 min, Article

Varenicline nasal spray trial for Dry Eye

An experimental varenicline nasal spray can reduce signs and symptoms of dry eye disease, the results of a phase 3 trial suggest. That's because Oyster Point's OC-01 works by stimulating…
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May 8, 2021 in Article, COVID-19

DCGI gives emergency approval of DRDO-developed anti-COVID oral drug

The Institute of Nuclear Medicine and Allied Sciences (Inmas) in collaboration with Dr Reddy’s Laboratories, Hyderabad, developed an anti-COVID-19 therapeutic application of the drug 2-deoxy-D-glucose (2-DG). The third phase of…
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May 8, 2021 in 1 min, Article

Four months TB regimen

A new drug combination containing rifapentine and moxifloxacin has finally broken the 6-month treatment barrier for drug-susceptible pulmonary tuberculosis, requiring only 4 months to produce a disease-free state at 1…
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May 8, 2021 in Article, New Drug

Torsemide over Furosemide as first line Loop Diuretic for HF

Three reasons why consider torsemide should be considered a first-line treatment for heart failure. In a trial published in 2001, researchers randomized 234 patients with heart failure to receive torsemide…
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May 8, 2021 in 1 min, Article

New oral protein shows promise for Ulcerative Colitis

A plant-based fusion protein is safe and effective for inducing favorable immune modulation in patients with mild to moderate ulcerative colitis with no immune suppression–side effects reported. OPRX-106, an orally…
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May 1, 2021 in Article, COVID-19

ECMO support in COVID-19 patients with refractory ARDS

COVID-19 patients treated with extracorporeal membrane oxygenation (ECMO) appear to have a much lower mortality rate than initial early reports suggested. ECMO has been utilized in COVID-19 patients with acute…
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May 1, 2021 in Article, FDA Update

FDA approves Dapagliflozin for Chronic Kidney Disease

The US Food and Drug Administration (FDA) has approved dapagliflozin (Farxiga, AstraZeneca) to reduce the risk for kidney function decline, kidney failure, cardiovascular death, and hospitalization for heart failure in…
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April 25, 2021 in Article, New Drug

Tralokinumab gets nod for Atopic Dermatitis in Europe

European Medicines Agency (EMA) issued a positive opinion for the IL-13 inhibitor tralokinumab (Adtralza) for the treatment of adults with moderate-to-severe atopic dermatitis (AD) who are eligible for systemic therapy.…
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April 25, 2021 in Article, COVID-19

DCGI approves Virafin, Pegylated Interferon alpha-2b for COVID-19

Zydus Cadila announced that it has received restricted emergency use approval from the Indian drug regulator, Drug Controller General of India (DCGI), for the use of ‘Virafin’, Pegylated Interferon alpha-2b…
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April 21, 2021 in Article, COVID-19

Role of Azithromycin in COVID-19

Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community randomised trials is lacking. Azithromycin might increase the pH of the…
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April 21, 2021 in Article, New Drug

Ublituximab + Ibrutinib for CLL

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease associated with several known genetic abnormalities, including 17p deletion (del), 11q deletion (del), and TP53 gene mutations, which are adverse prognostic…
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April 21, 2021 in Article, FDA Update

FDA approves oral contraceptive with new estrogen

The novel combined oral contraceptive, marketed as Nextstellis, contains 3 mg drospirenone (DRSP) and 14.2 mg of estetrol (E4) in tablet form. Estetrol is an estrogen that is naturally produced…
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April 18, 2021 in Article

New benznidazole treatment regimen for Chagas Disease shows promise

For treatment of Chagas disease, benznidazole can be taken for a shorter period of time and at lower doses with similar efficacy to the current standard regimen and is much…
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April 18, 2021 in 1 min, Article

Antibiotics in development not enough to tackle superbugs: WHO

None of the 43 antibiotics currently in development as well as recently approved medicines are enough to combat the increasing emergence and spread of antimicrobial resistance, the World Health Organization…
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April 15, 2021 in Article, COVID-19

What is the role of the antiviral drug remdesivir in the treatment of COVID-19?

Remdesivir was the first drug approved by the FDA for treating the SARS-CoV-2 virus. It is indicated for treatment of COVID-19 disease in hospitalized adults and children aged 12 years and…
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April 15, 2021 in Article, COVID-19

Brazil P1 coronavirus variant mutating is more dangerous

Brazil's P1 coronavirus variant, behind a deadly COVID-19 surge in the Latin American country that has raised international alarm, is mutating in ways that could make it better able to…
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April 11, 2021 in Article, FDA Update

FDA approves first AI device to detect colon lesions

The US FDA announced its first-ever approval of an artificial intelligence device to help find colon lesions during colonoscopy. The GI Genius (Cosmo Artificial Intelligence) identifies areas of the colon…
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April 8, 2021 in Article, COVID-19

Reactive Infectious Mucocutaneous Eruption associated with COVID-19

Formerly known as Mycoplasma-induced rash and mucositis, RIME has arisen as the preferred terminology to include mucocutaneous eruptions that are caused by other infectious agents. RIME secondary to SARS-CoV-2 infection,…
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April 8, 2021 in Article

Volanesorsen shows promise in Multifactorial Chylomicronemia

Volanesorsen significantly reduces triglyceride levels in patients with multifactorial chylomicronemia syndrome and may reduce acute pancreatitis events in these patients, according to results of the COMPASS trial. In an earlier…
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April 6, 2021 in Article

New HIV vaccine shows great results in phase 1 trial

The International AIDS Vaccine Initiative (IAVI) and Scripps Research have recently announced the results of an important Phase I clinical trial. The researchers tested a new vaccine approach designed to…
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April 4, 2021 in 1 min, Article

HCC risk reduced by aspirin in chronic viral hepatitis

HCC is the fourth-leading cause of cancer mortality worldwide, and is driven mostly by viral hepatitis B (HBV) and viral hepatitis C (HCV) infection. The risk of hepatocellular carcinoma (HCC)…
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April 4, 2021 in 1 min, Article

Chronic adverse events likely common after Anti-PD-1 therapy for Melanoma

Chronic immune-related adverse events (irAEs) associated with anti-programmed cell death-1 (PD-1) therapy for melanoma were more common than previously thought in a retrospective multicenter study. As reported in JAMA Oncology,…
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April 2, 2021 in 1 min, Article

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

When esophageal or gastroesophageal-junction cancer remains a threat after chemoradiotherapy and surgery because of residual pathological disease, treatment with the checkpoint inhibitor nivolumab doubles disease-free survival, according to the results…
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April 2, 2021 in 1 min, Article

BRCA1 & BRCA 2 mutations raise risk for Endometrial Cancer also

Women with a BRCA1 or BRCA2 mutation have an increased risk for endometrial cancer (EC), and the greatest risk is for the rare subgroup of serous-like and p53-abnormal endometrial cancers…
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March 31, 2021 in Article, New Drug

Quadruple medical therapy for Heart Failure

Quadruple therapy with an angiotensin receptor–neprilsyin inhibitor (ARNI), evidence-based β-blocker, mineralocorticoid receptor antagonist (MRA), and sodium glucose cotransporter 2 inhibitor (SGLT2i) may reduce risk of death by 73% over 2…
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March 30, 2021 in 1 min, Article

Higher calorie refeeding effective in teens with anorexia nervosa

Researchers examined data on adolescents (mean age 16.4 years) hospitalized with anorexia nervosa who were randomized to higher-calorie refeeding (n=60) or lower-calorie refeeding (n=51). Patients started higher-calorie refeeding (2,000 kcals/day,…
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March 29, 2021 in Article, New Drug

European Union approved Duvelisib for CLL and Follicular Lymphoma

European Union approval has been recommended for duvelisib (Copiktra) for patients with relapsed/refractory chronic lymphocytic leukemia (CLL) or refractory follicular lymphoma (FL) who have received at least two prior lines…
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March 28, 2021 in Article, FDA Update

FDA approves neuromodulation device to improve gait in MS

The US FDA has approved the Portable Neuromodulation Stimulator for the short-term treatment of walking impairments as a result of mild to moderate symptoms from multiple sclerosis (MS). PoNS is…
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March 28, 2021 in Article, FDA Update

FDA approves Transcatheter Pulmonary Valve for Congenital Heart Disease

The US FDA has approved Medtronic's Harmony Transcatheter Pulmonary Valve (TPV) System to treat severe pulmonary regurgitation in pediatric and adult patients who have a native or surgically repaired right…
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March 28, 2021 in 1 min, Article

A new genetic mutation in schizophrenia discovered

The discovery of this new gene, PCDHA3, could enhance the development of genetic-risk calculators "that may help us understand vulnerability to schizophrenia in high-risk individuals and identify individuals with schizophrenia…
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March 26, 2021 in 1 min, Article

FDA warns abuse of OTC decongestant potentially deadly

Abuse or misuse of the over-the-counter nasal decongestant propylhexedrine can cause serious harm that can lead to hospitalization, disability, or death, the US Food and Drug Administration (FDA) warns in…
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March 26, 2021 in Article

A 6 month multidrug regimen for MDR-TB trial is successful

The trial, called TB PRACTECAL, compared the current local standard of care with a six-month regimen of bedaquiline, pretomanid, linezolid, and moxifloxacin. The interim analysis included 242 patients and the…
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March 24, 2021 in Article, New Drug

FDA approves new ready to inject glucagon product

The US FDA has approved dasiglucagon (Zegalogue 0.6 mg/0.6 mL, Zealand Pharma) autoinjector and prefilled syringe for the treatment of severe hypoglycemia in people with diabetes aged 6 and older.…
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March 24, 2021 in Article, COVID-19

Double mutant variant of the coronavirus has been detected in India

A new "double mutant" variant of the coronavirus has been detected from samples collected in India. Officials are checking if the variant, where two mutations come together in the same…
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March 21, 2021 in 1 min, Article

Menopausal hormone therapy curbs nocturia by improving sleep

Hormone therapy as a possible solution for postmenopausal women with nocturia. A significant reduction in prevalence of nocturia ≥ twice per night was seen after treatment, as the prevalence decreased…
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March 21, 2021 in 1 min, Article

IDSA updates COVID-19 treatment guidelines

The Infectious Diseases Society of America (IDSA) continues to examine available and potential treatments as new evidence emerges. Combination use of the monoclonal antibodies bamlanivimab and etesevimab to treat outpatients…
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March 18, 2021 in Article

Interesting case of Ocular vicarious menstruation in India

A 25-year-old married woman recently went to the emergency room at a hospital in Chandigarh, India after she experienced haemolacria (crying tears of blood). Interestingly, she wasn’t in any pain…
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March 18, 2021 in 1 min, Article

Ertugliflozin, the (SGLT2) inhibitor has renal benefits also

Ertugliflozin, the sodium-glucose cotransporter 2 (SGLT2) inhibitor class, now has shown evidence of renal benefits roughly on par with the other three drugs. Treatment of patients with type 2 diabetes…
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March 18, 2021 in 1 min, Article

Omidubicel improves on umbilical cord blood transplants

Omidubicel, an investigational enriched umbilical cord blood product being developed by Gamida Cell for transplantation in patients with blood cancers, appears to have some advantages over standard umbilical cord blood.…
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March 18, 2021 in Article, COVID-19

CDC & WHO establish new threat levels for COVID-19 variants

The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) have established new criteria to classify variants of SARS-CoV-2, the virus that causes COVID-19. The criteria…
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March 17, 2021 in 1 min, Article

Roche is launching a SARS-CoV-2 variant test

Roche is launching a SARS-CoV-2 variant test to help monitor emerging coronavirus mutations. The test runs on widely used high-throughput systems and is for research purposes only. The new SARS-CoV-2…
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